Fig. 3: Relationship between circadian-affected DEGs and aging and longevity genes.
From: Circadian-driven tissue specificity is constrained under caloric restricted feeding conditions
a Enrichment analysis of three types of DEGs with aging and longevity genes. The “enriched” and “depleted” relationships are shown in red and blue, respectively. The odds ratio is indicated by the size of the circle. Fisher’s exact test was used for enrichment analysis, and the total gene set was the genes expressed in all samples. b Enrichment analysis of three types of DEGs with genes that oscillate in response to calorie and time restriction. Eight different intervention protocols were included: 06mo_CR.night.2 h, 06mo_CR.night.12 h, 06mo_CR.day.2 h, 06mo_CR.day.12 h, 19mo_CR.night.2 h, 19mo_CR.night.12 h, 19mo_CR.day.2 h, and 19mo_CR.day.12 h. Fisher’s exact test was used for enrichment analysis, and the total gene set was the genes expressed in all samples. c Functional enrichment analysis of aging-related diseases for circadian-affected DEGs, constitutive DEGs, and temporal DEGs. The enriched and depleted relationships are shown in red and blue, respectively. The odds ratio is illustrated by different colors. Fisher’s exact test was used for enrichment analysis, and the total gene set was the genes expressed in all samples. d Comparison of correlation coefficients between fatty acid metabolic genes and other genes with age. Error bars are the 95% confidence interval in boxplot. e–h Scatter plots showing the correlation between the expression levels of four circadian-affected DEGs (Acox3, Avpr1a, Crot, and Cyp4a32) and age. The Pearson correlation coefficient was used to calculate the correlation coefficient.
