Fig. 5: Weighted gene co-expression network analysis (WGCNA) of circadian-affected DEGs.
From: Circadian-driven tissue specificity is constrained under caloric restricted feeding conditions
a The co-expression network of liver samples visualized using a cluster diagram, with different types of DEGs assigned to the identified modules. b Identification of cycling modules with enrichment of circadian-affected DEGs, liver-specific aging genes, and rhythmic genes under caloric and time restriction conditions. The odds ratio is shown on the X-axis, and co-expression modules are shown on the Y-axis. Again, “enriched” is indicated by red dots, while “depleted” is indicated by blue dots. c Heatmap of the eight circadian modules ordered by circadian phase, showing module eigengene values. d Heatmap of the eight circadian modules ordered by circadian phase, showing averaged expression levels. e Functional annotation of the cycling modules, showing their involvement in processes such as response to protein folding, cell junction assembly, rRNA processing, rRNA metabolic processes, and small GTPase-mediated signal transduction.
