Fig. 6: Temporal similarity between all cytokine concentrations and MNG neural activity for all subjects, high responder, and low responder subgroups.

Normalized template matching was deployed to determine the temporal similarity between MNG derived (RNG and RCA) firing rate and each cytokine change over the 7-Hr protocol for all subjects (a), high responder subgroup (b), and low responder subgroup (c). The two-sided Wilcoxon Rank Sum test was employed to compare similarity scores between TNF-α and four other cytokines (IL-6, IL-8 and IL-1β, IL-10) (*=p < 0.05). Boxplot centerline: median; box limits: Q1 and Q3 quantile.