Fig. 2: Inhibitory KIR genes have increased chromatin accessibility in the CD8⁺ TIGIT⁺KLRG1⁺ CD57⁺ Tex population.

A Significance (-log10 FDR-adjusted p-value) and log2 fold change of differentially accessible sites between CD57⁺ Tex vs PD-1⁺ Tex populations sorted from CD8⁺ nonnaïve memory cells (n = 4 R, sampled at baseline and 104 wk post-treatment). NK-like genes expressed in the CD57⁺ Tex population are labeled. B Enriched protein–protein interaction network in differentially accessible genes with increased accessibility in the CD57⁺ Tex population. Edges are weighted by the strength of protein–protein interactions. The PPI enrichment p value was calculated using STRING. C Mean ATAC peak coverage for key NKRs and iKIRs with increased accessibility in CD57⁺ vs PD-1⁺ Tex populations shown for all three sample groups.