Fig. 3: Elys_NPC sites are mostly located within LADs.
From: Nucleoporin Elys attaches peripheral chromatin to the nuclear pores in interphase nuclei
a Screenshot from UCSC genome browser showing H3K27Ac (orange), Nup98_nucl (pink), Nup98_NPC (violet), Elys_embryo (red), Elys_S2 (yellow), Lam_embryo and Lam_Kc167 (brown) profiles, as well as the corresponding domains or sites of enrichment (rectangles over profiles) for the representative region of chromosome 2R. The 9-state chromatin model, RNA-seq in control S2 cells (from this work) and RefSeq genes are indicated below. The overlapped regions between Elys_embryo and Nup98_NPC sites (containing Elys_NPC peaks) are outlined by translucent rectangles (Elys_NPC peaks mostly coincide with the dips in Lam profiles). b, c Averaged Lam_Kc167, Lam_embryo, Elys_embryo, Elys_S2 and H3K27Ac profiles around Elys_NPC sites (b) or Elys_nucl sites (c) located within LADs (±2 kb from LAD boundaries) determined in Kc167 or in late embryos. d Screenshot from UCSC genome browser showing H3K27Ac (orange), Nup98_nucl (pink), Elys_embryo (red), and Nup98_NPC (violet) profiles, as well as the corresponding domains or sites of enrichment (rectangles over profiles) for the representative region of chromosome 2L. The 9-state chromatin model, RNA-seq in control S2 cells (from this work), and RefSeq genes are indicated below. The regions of high concordance between H3K27Ac, Nup98_nucl, and Elys_embryo profiles are outlined by translucent rectangles.
