Fig. 2: Dectin-2 is involved in the lethal damage.
From: An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice
a Schematic structures of N-glycans and the mannose core: black circle, α1,6-mannose (in main chain); blue circle, β-mannose; green circle, α1,3-mannose; light blue circle, α-mannose (linked to the phosphate group); red circle, α1,6-mannose; yellow circle, α1,2-mannose; light brown rectangle, Mannose10 core). b–d Survival rates of Balb/c mice, treated with the mixed anesthetics and LPS, were i.v. injected with 400 μg/20 g of (b) J-1012 and α-mannosidase-treated J-1012 (n = 8 female mice), (c) C. lusitaniae (n = 10 female mice), (d) C. stellatoidea, C. parapsilosis and S. cerevisiae N-glycan (n = 10 female mice) with LPS (15 μg/20 g) and the mixed anesthetics. e Survival rates of Balb/c mice pre-treated with clodronate liposome were analyzed with LPS, the mixed anesthetics and 400 μg/20 g J-1012 N-glycan (n = 6 female mice). f, g Survival rates of Balb/c and Dectin-2KO mice were analyzed with (f) the mixed anesthetics (n = 7 male + 3 female mice) and (g) medetomidine (18 μg/20 g) with LPS and 400 μg/20 g J-1012 N-glycan (n = 10 female mice). h Survival rates of Balb/c mice i.v. injected with dexmedetomidine (9 μg/20 g), LPS, and C. stellatoidea N-glycan (200 μg/20 g) in the presence of atipamezole (36 μg/20 g) (n = 10 female mice). All data shown are compiled from two or three independent experiments. Data were analyzed by the Wilcoxon test.
