Fig. 7: Illustration of the mechanism underlying the regulation of photoperiodic disruption in neutrophil recruitment. | Communications Biology

Fig. 7: Illustration of the mechanism underlying the regulation of photoperiodic disruption in neutrophil recruitment.

From: Histone lactylation-ROS loop contributes to light exposure-exacerbated neutrophil recruitment in zebrafish

Fig. 7

Photoperiodic interference affects the level of H3K18 lactylation, regulating the transcriptional activation of the duox gene and resulting in an increase in reactive oxygen species (ROS) levels. Additionally, H3K18 lactylation activates Akt expression. The generation of ROS further enhances the level of H3K18 lactylation, forming a positive feedback loop between histone lactylation and ROS. This positive feedback loop leads to excessive recruitment of neutrophil under LL condition.

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