Fig. 5: NOE contacts between the side chain methyl groups of MALT1(PCASP-Ig3)339–719 at the PCASP and Ig3 domains interface.
From: Insights into mechanisms of MALT1 allostery from NMR and AlphaFold dynamic analyses
a Overview of the side chains with methyl groups. b, c Zoomed areas in (a) are indicated as blue and green boxes, respectively. Based on the crystal structure of MALT1(PCASP-Ig3)339–719 in its apo form, a set of NOEs between the methyl groups were expected in our 4D NOESY experiments. For these, red and dashed black lines mark observed and unobserved NOEs, respectively. Distances (in Å) between the carbons of the methyl groups are indicated. The labels and side chains of the methyl-containing amino acids are also shown.
