Fig. 3: Difference in average beta values between AD patients and controls for each CpG analyzed. | Communications Biology

Fig. 3: Difference in average beta values between AD patients and controls for each CpG analyzed.

From: Exploring cross-tissue DNA methylation patterns: blood–brain CpGs as potential neurodegenerative disease biomarkers

Fig. 3

The y-axis shows the adjusted p-values by Benjamini-Hochberg on a logarithmic scale (-Log10(p)). The trace line represents the threshold for significant values (≥1.30). On the x-axis is the difference in average beta values (delta beta) between cases and controls, being positive when there is higher methylation of the CpG in the case group and negative when there is less methylation in the same group. a Comparison between DNA samples derived from blood samples from AD patients and health controls (GEO ID: GSE153712). b Comparison between 125 DNA samples derived from different brain regions of 18 AD patients and 135 from 21 health controls (GEO ID: GSE72778).

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