Fig. 6: PZ-2891 increases AFD susceptibility in S. cerevisiae, C. albicans and A. fumigatus. | Communications Biology

Fig. 6: PZ-2891 increases AFD susceptibility in S. cerevisiae, C. albicans and A. fumigatus.

From: Vitamin B5 metabolism is essential for vacuolar and mitochondrial functions and drug detoxification in fungi

Fig. 6

a Solid growth assays showing increased S. cerevisiae and C. albicans susceptibility to amphotericin B when potentiated by PZ-2891. The representative images are from two independent experiments, each performed in duplicates. b Liquid growth assays showing increased C. albicans susceptibility to amphotericin B (125 ng/mL) and caspofungin (3.9 ng/mL) is potentiated by PZ-2891. The growth was normalized to DMSO-treated wells (no drug=100% growth) and 200 µM amorolfine well (0% growth). Liquid growth assays were conducted in quadruplicate (n = 4) and the plotted graphs represent the average of 4 data sets ± SD. c, d Average colony diameter rate and captures of solid media assay (up to 72 h of growth) with A. fumigatus cells under caspofungin treatment (20 μg/ml) in the presence or absence of PZ-2891 (50 μM). The data in Fig. 6c represent an average of 3 independent experiments ± SD. The representative images in (d) are from three independent experiments.

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