Fig. 2: IntrinClock design strategy and performance.
From: Development of an epigenetic clock resistant to changes in immune cell composition
A Filtering strategy for CpG sites. B Filtering strategy for samples. C Visualization of the filtering process for differentiation-independent age-related CpGs. Blue CpGs (those correlated with age but not with being a naive cell) were included in the feature set, whereas gray CpGs were not. Dashed line indicates linear least-squared regression line of relationship between CpG age correlation and CpG CD8+ naive cell correlation. D Correlation between age and IntrinClock predicted age in a variety of tissues from the test set. E–H Individual correlation plots for specific tissues in the test set. I Epigenetic age vs. chronological age correlation plot for semen samples.
