Fig. 2: MATE proteins form six clades (groups A–F).
From: Characterization of a vacuolar importer of secologanin in Catharanthus roseus
Groups A–D correspond to plant MATEs, and groups E and F correspond to prokaryotic MATE proteins. CrMATE1 was classified into Group A along with MIA-producing species from the Apocynaceae family. Two other C. roseus isoforms, CrMATE21 and CrMATE88, are in Group B. Closely associated are OsPEZ1, OsPEZ2 (rice phenolic exporters) and NtMATE1, NtMATE2 (nicotine biosynthesis and transport). A fourth C. roseus isoform CrMATE2, was classified in Group C, along with Arabidopsis transporters AtALF5 (an efflux transporter involved in detoxification) and AtDTX18 (hydroxycinnamic acid amide transporter). Phylogenetic trees were generated using MEGA11 software and the Maximum Likelihood method and annotated with iTOL v6.
