Fig. 4: Anatomical loci of PD-specific features. | Communications Biology

Fig. 4: Anatomical loci of PD-specific features.

From: Contrastive machine learning reveals Parkinson’s disease specific features associated with disease severity and progression

Fig. 4

a An illustration of the method used to obtain a deformation field for each PD patient by calculating a synthetic control brain matched on shared (PD-unrelated) features and morphing it into the corresponding synthetic PD brain (PD-related). The average (b) and standard deviation (c) Jacobian determinants of deformation fields across all PD patients were then calculated (PPMI & SAHZJU, n = 861 biologically independent samples). On the top, the cortical region is displayed, whereas the underside showcases the subcortical, white matter, and cerebellar regions. Warm colors indicate decreased volumes, while cold colors denote increased volumes in synthetic PD brains when compared with synthetic control brains.

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