Fig. 6: Extended liver resection in mice under NAD+ treatment. | Communications Biology

Fig. 6: Extended liver resection in mice under NAD+ treatment.

From: Extracellular NAD+ response to post-hepatectomy liver failure: bridging preclinical and clinical findings

Fig. 6

Wild type male C57BL/6 mice of 8-10 weeks of age undergoing extended liver resection under 6 mg NAD+ (treatment) or saline (control) treatment versus sham surgery (laparotomy without resection). a Probability of survival compared with log-rank test for trend. b Post-operative weight deviation from baseline weight analysed with two-way ANOVA. c Plasma eNAD+ uptake of intraperitoneal NAD+ injections compared on post-operative day (POD) 5 with Kruskal-Wallis test. d Regenerative capacity of the liver following resection compared on POD 2 with the Mann-Whitney-U test. e Immunohistochemical markers for proliferation, Ki67 and PCNA, are displayed as percentages of proliferating cells on POD3 compared with Kruskal-Wallis test. f Blood albumin compared on POD2 and g glucose preservation in liver tissue on POD3, both analysed with Kruskal-Wallis test. h High cell proliferation rate and regeneration seen in Ki67 and H&E staining following extended liver resection under NAD+ treatment and post-operative fibrosis, steatosis; and i portal expansion with inflammation in the control group. Bars represent mean levels with scatter plot, error lines for standard deviation.

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