Fig. 3: FMO3 knockout inhibits the activation of ER stress signaling after I/R. | Communications Biology

Fig. 3: FMO3 knockout inhibits the activation of ER stress signaling after I/R.

From: Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia–reperfusion in mice

Fig. 3

a Principal component analysis (PCA) using all the identified genes from RNA sequencing data for WT (pink) and Fmo3−/− (blue) after I/R reveals in-group clusters with minimal overlap. b Volcano plots illustrating differentially expressed genes identified in Fmo3−/− vs WT groups. The blue dots denote downregulated genes, the red dots denote upregulated genes and the gray dots denote genes without significantly differential expression. Compared to the WT I/R group, 642 upregulated genes and 629 downregulated genes were identified in the Fmo3−/− I/R group. c Heatmap of significantly differential genes identified in kidney tissue between WT and Fmo3−/− groups. d The top ten enriched gene ontology biological process (GO-BP) terms of genes that exhibited an upregulation in the Fmo3−/− group (pink) and genes that exhibited a downregulation in the Fmo3−/− group (green) are presented below. e GSEA showing enrichment of gene signatures associated with response to ER stress between Fmo3−/− and WT group. The normalized enrichment scores (NES) and P values are shown in the plot. NES normalized enrichment score.

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