Fig. 1: Macrophage response to conidia is highly variable across A. fischeri strains. | Communications Biology

Fig. 1: Macrophage response to conidia is highly variable across A. fischeri strains.

From: Strain heterogeneity in a non-pathogenic Aspergillus fungus highlights factors associated with virulence

Fig. 1

A Survival of conidia (asexual spores) from 16 A. fischeri strains (DTO1 - DTO16) as estimated by the number of colony-forming units (CFU) recovered after 24 h (h) of exposure to bone marrow-derived macrophages (BMDMs) at 37 °C. The clinically derived and highly virulent A1163 strain of the major pathogen A. fumigatus was used as a reference. Boxplots show the mean and interquartile range; whiskers show max/min values of data that are within ±1.5× the interquartile range, respectively. B Pro-inflammatory cytokine levels produced by BMDMs after 48 h incubation with conidia at 37 °C. Lipopolysaccharide (LPS) and cell medium were used as positive and negative controls, respectively. Bars represent the mean of eight separate measurements carried out across two replicates. Error bars show standard deviation. Full statistics are presented in Fig. S7 and supplementary data file S7. Images are a combination of original artwork and open-source images (under a Creative Commons license CC BY 4.0) retrieved from PhyloPic (https://www.phylopic.org).

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