Fig. 2: Enhanced SHP2 degradation induced by E2B_aCS3.
From: Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes
a Representative immunofluorescence images of U2OS cells 24 h post-transfection with E2B_aCS3 mRNA, or isotype controls. Scale bar (lower right corner image) = 100 µm. b, c Dot plots showing mean cellular SHP2 levels and expressed HA-tagged protein levels from IF images in (a). Data from three biological replicates. Statistical significance was calculated using a one-way ANOVA.
