Fig. 7: Proposed mechanisms on calcium ion modulating KDM2B recruitment enzymatic core of BCOR-PRC1.1 to CpG islands. | Communications Biology

Fig. 7: Proposed mechanisms on calcium ion modulating KDM2B recruitment enzymatic core of BCOR-PRC1.1 to CpG islands.

From: Calcium modulates the tethering of BCOR-PRC1.1 enzymatic core to KDM2B via liquid-liquid phase separation

Fig. 7

In resting state, BCOR-PRC1.1 was recruited to CpG islands through interaction with KDM2B, leading to gene silence. After stimulation, concentration of nuclear Ca2+ is elevated. The elevated Ca2+ weakens the association between BCOR/PCGF1 and KDM2B, through neutralizing highly acidic Poly-D/E regions on linker of BCOR. Ca2+ also induces phase separation of BCOR/PCGF1. The elevated Ca2+ further promotes co-condensation of enzymatic core of BCOR-PRC1.1 with KDM2B on target loci via LLPS mechanism.

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