Fig. 3: The connections with the highest fingerprint undergo spatial reconfiguration during AD.
From: Fingerprints of brain disease: connectome identifiability in Alzheimer’s disease
A Geneva cohort; B ADNI cohort; spatial specificity matrices of FC-fingerprints for each group as measured using edge-wise intra-class correlations (ICC). Here we display ICC values, computed using bootstrapping for a subset of randomly chosen subjects, across 1000 bootstrap runs, and then averaged within each group. We show edges with ICC between the 5th and 95th percentile. C Overlap Geneva-ADNI; overlap across the two cohorts of spatial specificity matrices of FC-fingerprints. Matrices in (A, B) were binarized for ICC > 0.6 which is considered a ‘good’ ICC score55, and only overlapping edges are displayed. n edges = number of overlapping edges. Matrices in (A–C) are ordered according to seven cortical RSNs as proposed by ref. 91. VIS visual network, SMT somatomotor network, DA dorsal-attention network, SA salience network, L limbic network, FPN fronto-parietal network, DMN default-mode network, SBC subcortical regions.
