Fig. 5: Geometric properties show that perturbation trajectories are related to the density distribution of stimulated receptors.

Panels (A) and (B) show that the maximum distance reached from the starting point exhibits a strong linear correlation with the mean receptor density. In panels (C) and (D), in contrast, we show that there is no significant correlation between the maximum distance reached and the “structural divergence” (representing the spatial relationship between receptor maps and the weight vector of connections). This finding highlights the extent to which the model dynamics can be shifted independently of the spatial arrangement of receptors. E, F Dotted lines show the perturbational distance accumulated as the scaling increases. Solid lines indicate the quadratic regression fitted to the cumulative distances. The inset shows the “perturbational efficiency” (PE) for each receptor. The 5HT2A receptor has the highest PE despite reaching a similar overall perturbational distance than the 5HT1A.