Fig. 6: In vivo model confirms that SPRR1B+ keratinocytes are constitutively enriched in oral mucosa and are increased during both oral mucosa and skin wound healing.
From: SPRR1B+ keratinocytes prime oral mucosa for rapid wound healing via STAT3 activation
a, b Schematic diagram of the experimental design in mice wound healing model. (Fig. 6a: skin; Fig. 6b: oral. Created with BioRender.com). The skin and tongue tissue of mice during the wound healing process are shown on the right (skin: n = 3, oral: n = 3). c Immunofluorescence images of oral and skin samples on different days during wound healing. Scale bar: 100 µm. d, e Quantification of the mean fluorescence intensity of SPRR1B over a 500-pixel area on either side of the skin and oral wound (n = 3). Error bars are shown as mean ± SEM from n = 3. One-way analysis of variance (ANOVA) were performed (d, e). *p < 0.05, **p < 0.01, ***p < 0.001. ns not significant.
