Fig. 2: Structural‒functional coupling (SFC) differences between participants with progressive supranuclear palsy (PSP) and healthy controls (HC).
A The SFC pattern in patients with PSP and healthy controls. The prefrontal cortex exhibited higher coupling whereas the lateral temporal and frontoparietal areas showed lower coupling values. The PSP maintained this particular pattern. B The histogram shows the distributions of the mean SFC values in the PSP and control groups after regressing out the effects of age, sex, and age × sex. C Case‒control comparison (t-map) of regional SFC (first row, unthresholded). Twenty-seven cortical regions showed statistically significant differences (bottom row, p < 0.05, threshold by BH-FDR correction). D A density scatterplot of the mean regional SFC values of healthy controls (x-axis) and the case‒control t statistic (y-axis) (r = −0.1928, pspin = 0.0286). Most cortical regions have positive SFC in healthy controls, which increases in PSP patients compared with healthy controls (72.7% of regions), or positive SFC in healthy controls, which decreases in PSP patients compared with healthy controls (26.9% of regions).
