Fig. 4: Relationships between structural‒functional coupling (SFC) and histological gradients as well as various histological parameters.

The top two main histological gradients extracted from BigBrain based on the MPC matrix are displayed on the cortical surface. A The first histological gradient is anchored at one end in the frontal lobe and at the other end in the occipital region which is similar to the first structural gradient mentioned earlier. B The second histological gradient anchored at one end by the primary sensory and motor areas and at the other end by the transmodal association and limbic cortices. C We present histological gradients processed via the ENIGMA toolbox. Panels (D–F) show the correlation between SFC changes and the first and second histological gradients, whereas we validated the gradient patterns via the ENIGMA toolbox, which revealed that only the first histological gradient was related to SFC changes. G Differential distribution of histological first and second gradients in the Yeo 7 network. H Central moment parameters calculated on the basis of cellular staining variations were projected onto the cortical surface. I Different cellular parameters are significantly correlated with SFC, providing new insights at the cellular histological level into the neuropathological mechanisms of PSP. J Different central moment parameters and externopyramidization distributions in the Yeo 7 network.