Fig. 1: Cryo-EM structure of the ET-1–ETBR–DNGi complex.
From: Structure of endothelin ETB receptor–Gi complex in a conformation stabilized by unique NPxxL motif
a Cryo-EM density map of the ET-1–ETBR–DNGi–scFv16 complex. Green: ETBR, salmon: ET-1, magenta: DNGαi Ras-like domain, blue: Gβ, orange: Gγ, and gray: scFv16. The inset shows the ET-1 model with the corresponding density at a contour level of 4.0 σ. b Molecular model of the ET-1–ETBR–DNGi complex in the same view and color scheme as in a. c Comparison of the Gi-stabilized active state of ET-1–ETBR (green), partially active state of ET-1–ETBR (blue), and bosentan-bound inactive ETBR (red). Black arrows represent helical movements from inactive to active state of ETBR.
