Fig. 4: Interface between ETBR and Gαi.
From: Structure of endothelin ETB receptor–Gi complex in a conformation stabilized by unique NPxxL motif
a Close-up view of the interaction between ETBR and the α5 helix of Gαi. Hydrogen bonds are indicated by black dotted lines. b Schematic representation of direct contacts between ETBR and the α5 helix of Gαi. Hydrogen-bonded and hydrophobic contacts are indicated by dashed and solid lines, respectively. Receptor residues involved in hydrogen bonding are numbered according to Ballesteros–Weinstein numbering9, and Gαi residues involved in hydrogen bonding are numbered according to CGN numbering29. Gαi and conserved Gαq and Gαs residues are in magenta, homologous residues of Gαq and Gαs are in orange, and others are shown in yellow.
