Fig. 3: GRIN increases precision compared to other GWAS boosting methods.
From: Analyses of GWAS signal using GRIN identify additional genes contributing to suicidal behavior
a Using a later, higher powered GWAS as a gold standard, GRIN generated higher precision values compared to GWAB and NAGA across all traits tested except for Type 2 Diabetes (T2D1) at dramatically less stringent statistical significance thresholds. GRIN maintained higher or equivalent precision when only the statistical significance threshold was less stringent (No GWAS Boosting). b GRIN produces comparable values of recall to GWAB and NAGA but no GWAS boosting method recalls all possible signal from the later GWAS. Numbers above each point indicate total number of genes input to GRIN at each statistical significance threshold. CAD1/CAD2: Coronary artery disease releases 1 and 2 compared to release 3 results; DrinksPerWeek1: release 1 of Drinks Per Week compared to release 2 results; HDL1/HDL2: High Density Lipoprotein cholesterol releases 1 and 2 compared to release 3 results; Height1/2: releases 1 and 2 compared to release 3 results; LDL1/2: Low Density Lipoprotein cholesterol releases 1 and 2 compared to release 3 results; SCZ1/2: Schizophrenia releases 1 and 2 compared to release 3 results; SmokingInitiation1: Smoking Initiation release 1 compared to release 2 results; T2D1: Type 2 Diabetes release 1 compared to release 2 results; TC1/2: Total Cholesterol releases 1 and 2 compared to release 3 results; TG1/TG2: Triglycerides releases 1 and 2 compared to release 3 results.
