Fig. 2: Common miRNAs in SGA and space environment. | Communications Biology

Fig. 2: Common miRNAs in SGA and space environment.

From: To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants

Fig. 2

a Heatmap depicting miRNAs significantly regulated in SGA vs. controls (adj. p < 0.05) present in simulated spaceflight datasets. b Heatmap displaying miRNAs consistently regulated in the same direction between SGA vs controls and PBL samples or mouse plasma. Analysis focuses on 13 common miRNAs from the plasma comparison. For the heatmaps, log2(Fold-Change) is color-coded, with red shades indicating upregulated genes and blue shades indicating downregulated genes. Significance is denoted by * adj. p-value < 0.05 and # p-value < 0.05. c Correlation plot of log2(Fold-Change) values for the 13 miRNAs, indicating positive correlation in red shades and negative correlation in blue shades. d Radar plot illustrating homology of pre-miRNAs (red) and mature miRNAs (black) in humans and mice for the 13 common miRNAs in SGA and space.

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