Fig. 2: Network analysis of differentially regulated transcripts from overexpression of VapC13 or VapC26 in M. tuberculosis. | Communications Biology

Fig. 2: Network analysis of differentially regulated transcripts from overexpression of VapC13 or VapC26 in M. tuberculosis.

From: Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis

Fig. 2

The RNA-Seq data of parental, VapC13 and VapC26 overexpression strains was compared in a network depicting the top responses of nodes or genes. The network of differentially expressed common hub nodes, Rv2034 (A), Rv2011c (B) and Rv1990c (C), upon overexpression of VapC13 and VapC26 in M. tuberculosis are presented. These nodes are coloured according to their functional categories in mycobrowser. The shape of the nodes reflects the gene expression pattern. The circles and arrowheads represent the nodes with increased or decreased expression, respectively. The diamonds represent the genes that showed comparable expression levels in vector and toxin overexpression strains.

Back to article page