Fig. 6: In vivo survival of parental and various mutant strains of M. tuberculosis in guinea pigs.

The bacterial loads in the lungs and spleens of guinea pigs infected with various strains were determined at either 4 weeks or 8 weeks post-infection. The data shown in these panels is the mean ± SD of log10 CFU obtained from either 5 or 6 guinea pigs per strain per time point. P values depicted on the graphs were assessed using a two-tailed paired t-test. Source data is provided in Supplementary Data Set 4.