Fig. 5: Spt5p determines transcription directionality by controlling histone modification.
From: Spt5 orchestrates cryptic transcript suppression and transcriptional directionality
a Heatmaps illustrate the log2FC of each histone ChIP-seq signal (H3K36me3, H3K79me3, pan-acetyl H3, and pan-acetyl H4) normalized by H3 level and ranked by gene length in Spt5p-AID* and Bur1p-IS cells. The TSS and TES of each gene is represented by black dots. b Boxplots depict the log2FC of histone ChIP-seq and Input results for each group described in Fig. 4. Spt5p-AID* cells were treated with or without 1 mM IAA (upper) and Bur1p-IS strain cells were treated with or without 20 μM CMK (lower). p-values were calculated using Wilcox test.
