Fig. 5: drp-1 is epistatic to unc-89(sf22). | Communications Biology

Fig. 5: drp-1 is epistatic to unc-89(sf22).

From: Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function

Fig. 5

a Mitochondria are constantly undergoing fusion and fission, through the actions of several conserved GTPases of the dynamin family. The names of the nematode proteins are indicated with their mammalian orthologs shown in parentheses. b 3D rendering of SIM images of muscle mitochondria stained with anti-ATP5A. The drp-1 null mutant shows abnormally clumped mitochondria, whereas unc-89(sf22) shows fragmented (smaller) mitochondria. The double mutant, unc-89(sf22); drp-1(tm1108) shows the Drp-1 single mutant phenotype. Scale bar, 5 μm.

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