Fig. 3: Sequence analysis of LMBR1.
From: A dominant missense variant within LMBR1 related to equine polydactyly
a Sequence variation analysis of LMBR1. The structure of the gene with the black boxes for exons and lines between the boxes for introns. Ref represents the reference genotype of the variant site, and Alt represents the mutant genotype. Structural domain variants of LMBR1, where the standard position of the red line is the amino acid variation site; b 3D structure comparison between mutant and wild type protein; c multi-species covariance analysis. On the left is the phylogenetic tree of LMBR1, and on the right is the covariance analysis of the gene. Green and pink boxes represent exons, black lines connect exons that are homozygous between species, and pink boxes represent exons that are mutated. d Multi-species sequence similarity analysis for LMBR1. The upper part is a sequence similarity analysis and a demonstration of the degree of sequence similarity between species. The lower part is the similarity frequency of the sequence similarity of each site for each species compared to the horse.
