Fig. 1: Cell heterogeneity in kidney organoids differentiated from human iPSCs.

a Scheme of the induction protocol of kidney organoids from iPSCs. b Phase contrast images of kidney organoids at days 15, 19, 23, 27 and 31. Scale bars, 1 mm. c, d Uniform Manifold Approximation and Projection (UMAP) plot of kidney organoids colored by clusters (c) and differentiation day (d). e Dotplot of all clusters with known kidney marker genes.