Table 1 Top differentially expressed genes across comparisons between the putative ruptured side vs. putative unruptured side and the ruptured vs. unruptured side post-hCG
Gene name | Description/Function | Log2 Fold Change | P-value (adjusted) | |
|---|---|---|---|---|
Top DEGs no hCG Putative ruptured (positive) | Nap1l5 | Nucleosome assembly factor | 4.275 | 5.33E-17 |
Inhba | TGF-beta family | 4.216 | 6.85E-12 | |
Zpld1 | ECM constituent | 3.654 | 1.61E-10 | |
Hsd17b1 | Estrogen signaling dehydrogenase | 3.519 | 6.57E-12 | |
Paqr6 | Progesterone receptor | 3.373 | 0.000242 | |
Vwa5b1 | Von Willebrand factor extracellular protein | 3.136 | 3.51E-05 | |
Cyp19a1 | Estrogen biosynthesis enzyme | 3.130 | 1.11E-14 | |
Chst8 | Sulfotransferase | 2.881 | 3.33E-11 | |
Slc38a5 | Amino acid transporter | 2.797 | 2.30E-07 | |
Hsd11b2 | Cortisone signaling dehydrogenase | 2.771 | 4.59E-08 | |
Top DEGs no hCG Putative unruptured (negative) | RP24-149G20.1 | Unknown | −3.160 | 0.0404 |
C1s2 | Serine protease | −2.928 | 6.19E-07 | |
Hoxd10 | DNA-binding protein | −2.715 | 0.00429 | |
Fxyd1 | Ion transporter | −2.712 | 5.72E-05 | |
Ror2 | Tyrosine kinase | −2.690 | 1.33E-09 | |
RP23-42H18.6 | Unknown | −2.677 | 0.0378 | |
Stk32a | Serine/threonine kinase | −2.649 | 8.45E-05 | |
Fxyd5 | Ion transporter | −2.632 | 2.97E-06 | |
F2rl3 | Thrombin-like protein | −2.615 | 0.0315 | |
Ctss | Peptidase | -2.610 | 0.00430 | |
Top DEGs post-hCG Ruptured (positive) | Adam22 | Metallopeptidase | 2.254 | 5.34E-08 |
Gas1 | Cell cycle arrest protein | 2.092 | 1.85E-14 | |
Fst | FSH release inhibitor | 2.025 | 4.27E-11 | |
Ear6 | Ribonuclease | 2.013 | 0.00362 | |
Cdh15 | Cadherin | 1.896 | 2.60E-06 | |
Tspan2 | Tetraspanin | 1.720 | 4.86E-06 | |
RP23-56C21.4 | Unknown | 1.646 | 0.0110 | |
Porcn | Wnt signaling | 1.575 | 1.71E-06 | |
Kif2c | Kinesin | 1.561 | 0.00858 | |
Gnao1 | Signal transduction | 1.553 | 3.10E-18 | |
Top DEGs post-hCG Unruptured (negative) | Lama2 | Laminin | −7.435 | 4.94E-05 |
RP23-162H6.1 | Unknown | −6.863 | 4.40E-12 | |
Ly6a | Lymphocyte antigen | −6.816 | 0.00165 | |
Insl3 | Insulin-like hormone | −5.951 | 1.79E-11 | |
Serpinb2 | Endopeptidase inhibitor | −5.811 | 7.95E-17 | |
C3 | Complement activation | −5.581 | 6.86E-10 | |
Dhrs3 | Retinol metabolism | −5.170 | 1.78E-18 | |
Fgl2 | Fibrinogen-like protein | −5.130 | 2.15E-18 | |
Serpina3n | Protease inhibitor | −4.972 | 3.16E-16 | |
Col3a1 | Type III collagen | −4.937 | 1.83E-15 |
