Table 2 Genes driving biological processes identified from differentially expressed genes

Gene

Description/Function

Log2 FC

P-adj

Angiogenesis

Jcad

Endothelial junction protein

−0.744

2.70E-05

Nrp1

Cell migration regulator

−1.298

3.82E-06

Rhoj

Endothelial adhesion and angiogenesis regulator

−1.547

3.58E-05

Hdac7

Transcriptional regulator

−0.762

0.000487

Cxcl12

Intercrine GPCR ligand

−1.114

5.65E-05

Robo4

Regulator of cell adhesion and angiogenesis

−1.087

2.19E-05

Itgb1

Integrin protein

−0.611

0.000745

Amotl1

Tight junction component

−0.493

0.000641

Emp2

Epithelial membrane protein

-0.575

1.92E-05

Smooth muscle function

Ptger3

Prostaglandin receptor

−1.469

0.000427

Kit

Receptor tyrosine kinase

−1.694

1.24E-06

Pdpn

Membrane glycoprotein

−1.304

0.000459

Amino Acid Transport

Slc3a2

L-type amino acid transporter

0.743

0.000958

Slc7a8

L-type amino acid transporter

2.000

1.35E-05

Slc38a5

Sodium-coupled amino acid transporter

2.797

2.30E-07

Slc7a6

Basic amino acid transporter

0.449

7.36E-06

Slc6a15

Neutral amino acid transporter

1.110

0.000161

Oxidative Stress

Ddias

DNA Damage response

1.066

0.000497

Prkcd

Apoptotic regulator

1.084

1.11E-14

Trp53inp1

Autophagy regulator

0.859

5.47E-07

Cd36

Cell surface glycoprotein

1.698

5.20E-08

Hif1a

Hypoxia inducible factor

1.245

4.97E-10

Epas1

Oxygen responsive transcription factor

1.262

0.000252

Apoa4

Apolipoprotein

2.235

5.04E-06

Tissue morphogenesis and Jag-Notch signaling

Jag1

Notch ligand

1.308

2.84E-06

Notch2

Notch receptor

0.450

0.000584

0.000459

Gene

Description/Function

Log2 FC

P-adj

Response to copper

Muc2

Mucin protein

−2.173

2.96E-06

Mt1

Metallothionein

−1.173

3.77E-08

Mt2

Metallothionein

−0.997

7.09E-06

IL-11 signaling

Jak1

Protein tyrosine kinase

−0.369

0.000527

Il11

Cytokine

−1.935

0.000984

Stat3

STAT family member

−0.501

4.40E-09

Glycolytic processes

Eno2

Enolase enzyme

−1.373

7.61E-10

Tpi1

Isomerase

−0.856

2.03E-13

Pkm

Kinase

−0.667

7.19E-09

Pgk1

Kinase

−0.892

6.51E-08

Gapdh

Dehydrogenase

−0.318

0.000271

Galk1

Kinase

−0.809

1.51E-12

Aldoa

Aldolase

−0.394

1.75E-06

Hk1

Kinase

−0.632

8.63E-06

Pfkl

Kinase

−0.971

1.23E-16

Eno1

Enolase enzyme

−0.641

2.65E-09

BMP signaling

Fst

Follistatin

2.025

4.27E-11

Heyl

Transcription factor

1.165

0.000148

Comp

Matrix protein

1.293

2.20E-06

Sfrp2

Secreted frizzled receptor

1.064

1.63E-05

Inhbb

Inhibin

1.396

4.31E-06

Notch2

Notch receptor

0.403

0.000684

Runx2

Transcription factor

0.752

7.44E-09

Bmper

BMP binding protein

0.554

0.000152