Fig. 1: Sensitivity of gut bacterial isolates against ivermectin (IV) and moxidectin (MX). | Communications Biology

Fig. 1: Sensitivity of gut bacterial isolates against ivermectin (IV) and moxidectin (MX).

From: Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation

Fig. 1

A AUC ratios of aerobically incubated isolates for IV and MX at concentrations of 1 µM, 5 µM and 10 µM. B AUC ratios of anaerobically incubated isolates for IV and MX at concentrations of 1 µM, 5 µM and 10 µM. C AUC ratios of 25 MX-sensitive isolates visualized across three concentrations (1 µM, 5 µM, 10 µM). Values belonging to the same isolate are connected with a dotted line. Coloring was chosen according to the isolate genus. In the boxplot, the box represents the interquartile range, contains a median line and whiskers indicate the 95% CI. D AUC ratios of 19 IV-sensitive isolates visualized across three concentrations (1 µM, 5 µM, 10 µM). Values belonging to the same isolate are connected with a dotted line. Coloring was chosen according to the isolate genus. In the boxplot, the box represents the interquartile range, contains a median line and whiskers indicate the 95% CI. E, F Fold change (FC) ratio for sensitive isolates. FC was calculated as 1–(AUCIV / AUCMX). 1–FC > 0 indicates a higher sensitivity towards IV, 1–FC < 0 indicates higher sensitivity towards MX. The figure is stratified by aerobic (E) and anaerobic (F) incubations.

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