Fig. 3: Inter-family variability of the paternal age effect among the IRASFS multi-child families. | Communications Biology

Fig. 3: Inter-family variability of the paternal age effect among the IRASFS multi-child families.

From: Mutational signature analyses in multi-child families reveal sources of age-related increases in human germline mutations

Fig. 3

A Scatter plots of the numbers of de novo SNVs for each family relative to the father’s age at each child’s birth, ordered by slope from the lowest (top with blue color, IRASFS Family 09) to the highest rate (bottom right with red color, IRASFS Family 05). Regression lines and 95% confidence intervals indicate the predicted number of de novo SNVs as a function of paternal age using a Poisson regression. B Slope ± 95% confidence interval (CI) of each IRASFS family sorted in order of increasing slope as in A. The dashed vertical line indicates the paternal age effect based on the combined data from all families (1.29 de novo SNVs/year, 95%CI: 1.44–1.57, p < 0.0001).

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