Fig. 10: Neuroligin-3 knockdown mitigates fear memory, anxiety, and alters recruitment of associative memory neurons in the S1-Tr Cortex of Intruder Mice. | Communications Biology

Fig. 10: Neuroligin-3 knockdown mitigates fear memory, anxiety, and alters recruitment of associative memory neurons in the S1-Tr Cortex of Intruder Mice.

From: Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation

Fig. 10

Intruder mice exhibit fear memory, anxiety, and increased recruitment of associative memory neurons in the S1-Tr cortical region. These behavioral and neuronal alterations are mitigated by neuroligin-3 knockdown in the S1-Tr cortex, which leads to a reduction in dendritic spines and synapse contacts. Specifically, intruder mice show heightened firing frequency of associative memory neurons in response to tactile and auditory stimuli, and this effect is alleviated by the knockdown of neuroligin-3. (Created in BioRender. Chen, B. BioRender.com/s66k028).

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