Fig. 1: JmjC-KDM catalysed KDM and RDM reactions. | Communications Biology

Fig. 1: JmjC-KDM catalysed KDM and RDM reactions.

From: JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships

Fig. 1

JmjC KDM (a) / RDM (b) catalysed N-methyl lysine- and arginine-demethylation occurs via unstable hemiaminal-type intermediates. Note only the mono-methylated (me1) and asymmetric di-methyl (me2a) forms of N-methylated Arg are shown. Each 2OG oxygenase catalysed oxidation is coupled to conversion of 2OG / O2 to succinate / CO2.

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