Fig. 6: Schematic representation of PI3K-AKT-CASP3 axis of oysters in facing high temperature. | Communications Biology

Fig. 6: Schematic representation of PI3K-AKT-CASP3 axis of oysters in facing high temperature.

From: PI3K-AKT-mediated phosphorylation of Thr260 in CgCaspase-3/6/7 regulates heat-induced activation in oysters

Fig. 6

Under thermal stress, the PI3K/AKT pathway is activated via RTKs (Receptor Tyrosine Kinases) or ITGs (Integrins). Then, upregulated CgPI3K complex in C. angulata catalyzes PIP2 to PIP3, which recruits CgPDK1 (the phosphorylation level of the Ser184 autophosphorylation site is increased in C. angulata) to phosphorylates CgAKT Thr291 site. Additionally, the phosphatase PP2A/PTEN, dephosphorylating the Thr291 sites of CgAKT/dephosphorylating phosphoinositides to suppress the PI3K-AKT pathway, also shows stronger downregulation in C. angulata, indicating its involvement in regulating the higher kinase activity of CgAKT in C. angulata. Finally, stronger activated CgAKT phosphorylates CgCASP3 Thr260 site to inhibit its heat-induced activation to shape lower CASP3 enzyme activity and stronger thermal resistance of C. angulata.

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