Fig. 8: Model depicting how DNRX bridges DG to the heterodimeric glycosyltransferase complex RT/TW for its glycosylation. | Communications Biology

Fig. 8: Model depicting how DNRX bridges DG to the heterodimeric glycosyltransferase complex RT/TW for its glycosylation.

From: Neurexin facilitates glycosylation of Dystroglycan to sustain muscle architecture and function in Drosophila

Fig. 8

In wild-type files, glycosylation modification of nascent DG (green DG) begins in the ER, matures (green DG modified by glycans) in the Golgi apparatus, and finally, glycosylated DG reaches the plasma membrane. DNRX recruits the RT/TW heterodimer to DG through its interaction with RT, facilitating the glycosylation of DG. Glycosylated DG is then transported to the cell surface, where it carries out its proper function. However, in dnrx mutants, lightly glycosylated DG (red DG) cannot reach the RT/TW heterodimer due to DNRX deficiency, resulting in reduced DG glycosylation and accumulation in the cytoplasm through an unknown mechanism (red dashed DG). Although some of the lightly glycosylated DG can be transported to the cell surface, decreased levels of DGs are present at the cell membrane.

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