Fig. 1: SSa effectively limited liver injury in chronic-plus-binge ethanol-fed mice.
From: Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism
A Schematic representation of the experiment, and timeline of administration of SSa solution. B SSa influenced the reduced body weight of mice administered with ethanol from day 12 to day 19 (n = 6 per group). Data are represented as the mean ± SD, *p < 0.05, **p < 0.01 between the two groups. C The levels of liver/body weight index (n = 6). D, E representative liver H&E staining (Bar:200 and 60 µm) and Oil Red O staining images from mice with ALD and/or SSa cotreatment (Scale Bar: 100 and 75 µm) (n = 3). F Differences in plasma biochemical parameters (ALT, AST, TC, TG, and γ-GT) in mice cotreated with ALD and/or SSa (n = 6). G Alterations in hepatic parameters (TC, TG, and NAD+/NADH) in mice with ALD and/or SSa cotreatment (n = 6).
