Fig. 6: SIRT1-PPAR-α/mTOR transmits oral SSa solution-mediated protection signals in ALD mice.
From: Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism
A Protein level alterations in total mTOR, phosphorylated mTOR SIRT1, PGC- 1α, PPAR-α, and Deptor with ALD and/or SGA cotreatment, with or without hepatic SIRT1 knockdown (Day 50) (n = 3). B, C mRNA abundance of hepatic SREBP- 1C, PPAR-α and their target genes with ALD and/or SSa treatment, with or without hepatic SIRT1 knockdown (n = 6). D, E Representative confocal microscopy images (Scale Bar:20 µm) of immunostaining of SREBP- 1C in mouse liver, and quantification of the SREBP- 1C positive area (n = 3).
