Fig. 5: Sex differences in mucosal immune cell infiltration into different regions of the colon.
From: Spatial profiling of the mouse colonic immune landscape associated with colitis and sex
a Th cell, B cell, neutrophil, Tc cell, and M2-like macrophage infiltration in the different regions of the colon at homeostasis (vehicle-treated, n = 3 for each sex). b M2-like macrophage, B cell, and Tc cell infiltration into the different regions of the colon in response to colitis (vehicle: n = 3 of each sex, AOM/DSS: n = 5 of each sex). c NK cell infiltration and (d) neutrophil infiltration in regions of squamous metaplasia compared to in different regions of the inflamed colon in treated males (n = 5) and females (AOM/DSS: n = 5 for regions of the colon and n = 4 for squamous metaplasia, per sex). e Representative images of neutrophil infiltration (Ly-6G in magenta) in regions of squamous metaplasia in males (left) and females (left). Results are given as mean ± SEM (a–d). Statistical analysis was performed using two-way ANOVA tests with Fisher’s LSD test (a, b) or one-way ANOVA tests with Fisher’s LSD test (c, d). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. # indicates significant sex differences (b). SM = squamous metaplasia (c, d). Scale bars: 50 μm (e). Males (green) and females (purple).
