Fig. 4: Volcano plot of differential abundance.

A Non-viral microbes and B viral host genus by sample type and host depletion treatment. Each dot represents association analyzed by differential abundance analysis. Microbial taxa that showed strong significant changes (q-val < 0.01, |effect size| > 2) and viral host genus with significant changes (q-val < 0.1, |effect size| > 0.3) were labeled with their names. The analysis was conducted with linear mixed-effect model (feature ~ sample type + lyPMA + Benzonase + HostZERO + MolYsis + QIAamp, random effect = subject id) after centered-log ratio normalization.