Fig. 3: Left atrial (LA) non-immune cell landscape in atrial fibrillation (AF); the interactions between non-immune cells (snRNA-seq data) and myeloid cells (scRNA-seq data). | Communications Biology

Fig. 3: Left atrial (LA) non-immune cell landscape in atrial fibrillation (AF); the interactions between non-immune cells (snRNA-seq data) and myeloid cells (scRNA-seq data).

From: Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation

Fig. 3

A Uniform manifold approximation and projection (UMAP) of fibroblasts (FBs) in the left atria (LA) of patients with atrial fibrillation (AF) (n = 5). Proportions of each FB sub-cluster. B Dot plot displaying signature cell gene expression markers for each FB cluster. C Cell-Chat analysis of EGF, PDGF, FN1, and COLLAGEN interactions between myeloid cells and FBs. D UMAP of endothelial cells (ECs) in LA (patients with AF) (n = 5). Proportions of each EC sub-cluster. E Dot plot displaying SCGEMs for each EC cluster. F Cell-Chat analysis of VEGF, IL1, IGF, and NOTCH interactions between myeloid and ECs. G UMAP of cardiomyocytes (CMs) in LA (patients with AF) (n = 5). Proportions of each CM sub-cluster. H Dot plot displaying signature cell gene expression markers for each CM cluster. I Cell-Chat analysis of IGF and EGF interactions between myeloid cells and CMs.

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