Table 2 Lead variants from 1KG+7K mapping outside previously reported loci (Kanai et al., 2018) not significant in TOPMed
Serum uric acid levels | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Locus | Chr | rs ID | Position | Major allele | Minor allele | Imputation up to TOPMed panel | Imputation up to 1KG+7K panel | ||||||||
MAF | Beta | SE | p-value | r2 | MAF | Beta | SE | p-value | r2 | ||||||
SRGAP2-AS1/LINC02798 | 1 | rs1156692814 | 121,432,234 | G | C | NA | NA | NA | NA | NA | 0.0092 | –0.1746 | 0.0320 | 4.9.E–08 | 0.494 |
SLC22A13 | 3 | rs117371763 | 38,317,479 | C | T | 0.0261 | –0.0748 | 0.0148 | 4.2E–07 | 0.833 | 0.0483 | –0.0667 | 0.0105 | 1.8.E–10 | 0.921 |
PSORS1C1/PSORS1C2 | 6 | rs2233950 | 31,106,065 | C | T | 0.0462 | –0.0510 | 0.0103 | 8.0E–07 | 0.982 | 0.0412 | –0.0611 | 0.0108 | 1.4.E–08 | 1.000 |
MAP7 | 6 | rs78302547 | 136,860,353 | A | C | NA | NA | NA | NA | NA | 0.0071 | –0.1704 | 0.0299 | 1.3.E–08 | 0.730 |
NRG4 | 15 | rs12595289 | 76,251,105 | G | A | 0.1534 | –0.0257 | 0.0066 | 1.0.E–04 | 0.814 | 0.1750 | –0.0381 | 0.0061 | 5.0.E–10 | 0.852 |
Total Cholesterol Levels | |||||||||||||||
Locus | Chr | rs ID | Position | Major allele | Minor allele | Imputation up to TOPMed panel | Imputation up to 1KG+7K panel | ||||||||
MAF | Beta | SE | p-value | r2 | MAF | Beta | SE | p-value | r2 | ||||||
PPIA/H2AZ2 | 7 | rs899749693 | 44,862,003 | C | A | NA | NA | NA | NA | NA | 0.0023 | –0.2622 | 0.0441 | 2.7E–09 | 0.873 |
