Fig. 2: Kcnb1^R312H(+/+) mice present severe cognitive impairment.

A Percentage of nesting material used and nesting score (see methods) for WT and Kcnb1^R312H(+/+) (R312H) mice. B Mean number of marbles buried by WT and Kcnb1^R312H(+/+) mice. C Violin plot of the magnitude of response to a visual looming threat for WT and Kcnb1^R312H(+/+) mice. N = 5 mice/genotype. D Time spent in the safe zone of the visual cliff arena for WT and Kcnb1^R312H(+/+) mice. E Violin plot of the magnitude of response to a startling sound of WT and Kcnb1^R312H(+/+) mice. N = 8 mice/genotype. F Representative heat maps of the distance traveled and quantifications of the comebacks to the house, mean speed, and distance traveled in the dead reckoning test by WT and Kcnb1^R312H(+/+) mice. Scale bars 20 cm. G Latency to fall in the hanging test for WT and Kcnb1^R312H(+/+) mice. In all behavioral tests, three-month-old mice were used. ^*P < 0.05, ^***P < 0.001, and ^****P < 0.0001, two-tailed student’s t-test.