Fig. 7: Characteristics and experimentally verified signaling pathway of hepsin-induced hepatocyte proliferation.

a Mechanism of hepatocyte proliferation induced by the hepsin-mediated EGFR (epidermal growth factor receptor) signaling pathway. b Summary of the time course of hepsin-induced hepatocyte proliferation in adult mice via AAV-mediated overexpression. The upregulated signaling upon hepsin overexpression is highlighted in a blue box. N.D. not detected.