Fig. 1: The frequency of IGF-1 c.258 A > G distribution and incidence of osteoporosis.
From: IGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosis

a The incidence of osteoporosis in individuals aged over 50 years. b Homology alignments of IGF-1 exon 4 in human and Mus musculus, the red dotted box referred to the synonymous mutation site of c.258 A > G. c Human IGF-1 c.258 A/G folding in different regions and countries.